Blar i forfatter "Choi, Seong Won"

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    • Mammalian Atg8 proteins regulate lysosome and autolysosome biogenesis through SNAREs 

      Gu, Yuexi; Abudu, Yakubu Princely; Kumar, Suresh; Bissa, Bhawana; Choi, Seong Won; Jia, Jingyue; Lazarou, Michael; Eskelinen, Eeva-Liisa; Johansen, Terje; Deretic, Vojo (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-10-18)
      Mammalian homologs of yeast Atg8 protein (mAtg8s) are important in autophagy, but their exact mode of action remains ill‐defined. Syntaxin 17 (Stx17), a SNARE with major roles in autophagy, was recently shown to bind mAtg8s. Here, we identified LC3‐interacting regions (LIRs) in several SNAREs that broaden the landscape of the mAtg8‐SNARE interactions. We found that Syntaxin 16 (Stx16) and its cognate ...

    • TAK1 converts Sequestosome 1/p62 from an autophagy receptor to a signaling platform 

      Kehl, Stephanie R; Soos, Brandy-Lee A; Saha, Bhaskar; Choi, Seong Won; Herren, Anthony W; Johansen, Terje; Mandell, Michael A (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-07-25)
      The protein p62/Sequestosome 1 (p62) has been described as a selective autophagy receptor and independently as a platform for pro‐inflammatory and other intracellular signaling. How these seemingly disparate functional roles of p62 are coordinated has not been resolved. Here, we show that TAK1, a kinase involved in immune signaling, negatively regulates p62 action in autophagy. TAK1 reduces p62 ...